These powerful compounds can improve heart health, weight management, mood, and more

Grape seed extract, made from crushed grape seeds, contains high levels of proanthocyanidins, the polyphenols that give grapes their red and purple colors. Heralded for its strong antioxidant activity, Grape Seed extracts have increased in popularity as a functional food.

In 2020, the grape seed extract market surpassed $135 million and its compound annual growth rate is expected to reach 7.5 percent by 2027.[i]

While partly due to its use in cosmetics, personal care products, and other newer products — such as nanofibers containing grape seed extract powder, which are incorporated into food packaging to prevent oxidation in foods — health-conscious consumers are increasingly interested in grape seed extract as a supplement. or addition to functional foods and beverages.[ii] If you are thinking of giving it a try, here are some of its main benefits.

1. Prevention and Management of Obesity

A variety of actions, including lowering blood lipids, improving gut flora, and regulating metabolism, make grape seed extract beneficial for obesity. “It can effectively prevent obesity in many ways,” wrote researchers from the Medical School of Yangtze University in Jingzhou, China.[iii]

When taken in conjunction with a calorie-restricted diet, grape seed extract (300 milligrams (mg) daily for 12 weeks) led to increased cardiovascular risk factors among obese or overweight adults.[iv] Compared with placebo, levels of beneficial high-density lipoprotein cholesterol increased in those taking grape seed extract while low-density lipoprotein cholesterol was significantly reduced.

Visceral fat, plasma atherogenic index (a marker of cardiovascular disease), and triglycerides were also significantly decreased in the grape seed extract group.

2. Blood Pressure Support

Grape seed extract appears to have blood pressure lowering effects, as well as heart rate-lowering properties.[v] In healthy adults, taking grape seed extract (300 mg daily for 16 weeks) significantly modulated blood pressure compared with placebo,[vi] while among obese and overweight men, grape seed extract reduced arterial pressure at rest and during exercise, through a substantial reduction in aortic stiffness.[vii]

Even among people with metabolic syndrome, the potent vasodilator phenolic compounds in grape seed extract were effective, lowering systolic and diastolic blood pressure compared to placebo.[viii] Grape seed extract has also been proposed as an intervention to minimize the potential increase in cardiovascular events that can occur during exercise in people with prehypertension.

While placebo had no effect, grape seed extract—taken as a single dose before exercise—reduced blood pressure, peripheral vasoconstriction, and cardiac work, while increasing oxygen delivery among men with prehypertension.[ix]

3. Relieve Stress and Improve Mood

Perceived stress and other mental components can have a significant effect on blood pressure. This is why the researchers measured not only the effect of grape seed extract on blood pressure but also on the participants’ level of perception emphasize. Grape seed extract provided surprising benefits on mood associated with the perception of stress, including a statistically significant reduction in worry.[x]

Previous research has also found that postmenopausal women who took grape seed extract experienced a reduction in systolic blood pressure along with improvements in psychological symptoms such as anxiety.[xi] The mood benefits could be due to grape seed extract polyphenols, which are associated with better mood and improved cognitive function along with protective effects against brain disease.[xii]

4. Supports Dental Health

A systematic review of 20 studies revealed that grape seed extract has unique properties that facilitate prevention dental caries. In addition to inhibiting bacterial biofilms on tooth surfaces, grape seed extract helps promote tooth remineralization, a natural process that helps repair tooth enamel before cavities develop.[xiii]

Several properties of grape seed extract—including antibacterial, antioxidant, and anti-inflammatory—make it ideal for promoting oral health and managing periodontal disease.[xiv] Grape seed extract gel also caused significant improvement in gingival and plaque index in people with chronic periodontitis.[xv]

5. Increases Insulin Resistance

Grape seed extract, with its strong anti-inflammatory and antioxidant effects, may have several beneficial effects on diabetes, including improving insulin resistance. Among adolescents with metabolic syndrome, taking grape seed extract for eight weeks (100 mg daily) improved insulin concentration and insulin resistance.[xvi]

Grape seed extract polyphenols also affect neuroregulatory factors and neural signaling pathways, which may have beneficial effects on insulin. About diabetesGrape seed extract positively affects enzymes for starch digestion in humans and also improves the condition of patients with microalbuminuria,[xvii] early signs of blood vessel damage[xviii] which is present in about 37 percent of people with type 2 diabetes and often precedes the development of diabetic nephropathy.[xix]

6. Heart Health

In addition to reducing blood pressure, grape seed extract provides a number of additional benefits for heart health. Research shows it significantly reduces C-reactive protein (CRP).[xx] CRP can reveal your risk of developing cardiovascular problems. Grape seed extract also helps prevent atherosclerosis, or hardening of the arteries, by:[xxi]

  • Limiting LDL . oxidation
  • Lowering blood pressure
  • Reduce inflammation
  • Inhibits platelet aggregation
  • Activates certain proteins, which prevent cell aging

Grape seed extract also helps minimize fat accumulation in adipose tissue and even inhibits the absorption of dietary fat through its effects on fat-metabolizing enzymes.[xxii] Overall, these natural grape compounds exert a powerful effect that reduces oxidative stress in the heart, helping to lower cardiac dysfunction.[xxiii] has compiled an impressive 86 pharmacological actions associated with grape seed extract, as well as 190 diseases they may affect.[xxiv] When taken in moderation, grape seed extract is usually well tolerated, according to the NIH National Center for Complementary and Integrative Health.

Human studies lasting up to 11 months also support its safety,[xxv] but for optimal use and dosage, consult your holistic health care practitioner.


[i] Global Market Insight Grape Seed Extract Market Size 2020 Base Year

[ii] Global Market Insights Grape Seed Extract Market Size 2020 Base Year

[iii] Obesity Facts. 2020 May; 13(2): 279-291.

[iv] Phytother Res. 2021 February;35(2):987-995. doi:10.1002/ptr.6859. Epub 2020 October 12.

[v] Pharmacol Res. 2022 Jan;175:105905. doi: 10.1016/j.phrs.2021.105905. Epub 2021 17 November.

[vi] Nutrition. 2021 February; 13(2): 654.

[vii] Sports Science Eur J. 2021 May 20:1-8. Epub 2021 20 May. PMID: 33905304

[viii] Metabolism. 2009 Dec;58(12):1743-6. doi:10.1016/j.metabol.2009.05.030. Epub 2009 15 July.

[ix] J Med Food. 2018 May;21(5):445-453. doi:10.1089/jmf.2017.0133. Epub 2018 April 23.

[x] Nutrition. 2021 February 17 ;13(2). Epub 2021 February 17th. PMID: 33671310

[xi] Nutrition. 2021 February 17 ;13(2). Epub 2021 Feb 17. PMID: 33671310 /article/grape-seed-extract-positively-modulates-blood-pressure-and-perceived-stress

[xii] Nutrition. 2021 February 17 ;13(2). Epub 2021 February 17th. PMID: 33671310

[xiii] Nutritional Health. 2020 Mar;26(1):43-52. doi: 10.1177/026010601987890. Epub 2019 November 24.

[xiv] J Biol Regular Homeost Agent. Mar-Apr 2021;35(2 Suppl. 1):89-96. doi:10.23812/21-2supp1-8.

[xv] J Investigating Clin Dent. 2018 May;9(2):e12318. doi:10.1111/jicd.12318. Epub 2018 January 18.

[xvi] Diabetes Metab Syndrome. Jan-Feb 2021;15(1):197-203. doi: 10.1016/j.dsx.2020.12.028. Epub 2020 December 23.

[xvii] Molecule. 2020 November; 25(22): 5311.

[xviii] Hippocrates. 2007 July-Sep; 11(3): 105-107.

[xix] India J Nephrol. 2009 April; 19(2): 53-56. doi: 10.4103/0971-4065.53322

[xx] Mr J Nutr. 2020 Sep 14:1-41. Epub 2020 Sep 14. PMID: 32921322

[xxi] J Food Science Technol. 2020 April; 57(4): 1205-1215.

[xxii] J Food Science Technol. 2020 April; 57(4): 1205-1215.

[xxiii] J Food Science Technol. 2020 April; 57(4): 1205-1215.

[xxiv] Grape Seed Extract

[xxv] NIH National Center for Complementary and Integrative Health Grape Seed Extract

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